diazepam decreases amounts of acetaminophen rectal by raising metabolism. Slight/Importance Unidentified. Improved metabolism incr amounts of hepatotoxic metabolites. Keep an eye on Closely (1)mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is a strong inducer of cytoch